High-level SAE2 promotes malignant phenotype and predicts outcome in gastric cancer [Retraction].
ثبت نشده
چکیده
[This retracts the article on p. 589 in vol. 5, PMID: 25973299.].
منابع مشابه
High-level SAE2 promotes malignant phenotype and predicts outcome in gastric cancer.
BACKGROUND The SUMO pathway has been shown to play an important role in tumorigenesis. This report analyzed the involvement of the sole SUMO-Activating Enzyme Subunit 2 (SAE2) in human gastric cancer (GC) progression and prognosis. METHODS Expression of SAE2 was examined by Quantigene Plex, western blotting and immunohistochemistry. The expression of SAE2 and c-MYC were detected in parallel i...
متن کاملInhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells
Autophagy defect has been shown to be correlated with malignant phenotype and poor prognosis of human cancers, however, the detailed mechanisms remain obscure. In this study, we investigated the biological changes induced by autophagy inhibition in gastric cancer. We showed that inhibition of autophagy in gastric cancer cells promotes epithelial-mesenchymal transition (EMT) and metastasis, alte...
متن کامل5-Year Survival in Gastric Adenocarcinoma with Epithelial and Stromal Versican Expression
Background & Objective: Gastric cancer is the second most frequent cause of cancer death worldwide, despite differences in incidence around the world. The majority of gastric cancer cases concern gastric adenocarcinoma, which has a fairly high 5-year survival rate when coupled with early-stage diagnosis. Versican, a member of the aggregating chondroitin sulfate proteoglycans fa...
متن کاملModeling Breast Acini in Tissue Culture for Detection of Malignant Phenotype Reversion to Non-Malignant Phenotype
Backgrounds: Evidence is accumulating to support disruption of tissue architecture as a powerful event in tumor formation. For the past four decades, intensive cancer research with the premise of “cancer as a cell based-disease” focused on finding oncogenes or tumor suppressor genes. However, the role of the tissue architecture was neglected. Three dimensional (3D) cell cultures which can recap...
متن کاملTrefoil factor 1 elevates the malignant phenotype of mucinous ovarian cancer cell through Wnt/β-catenin signaling.
Mucinous ovarian cancer accounts for almost 10% of epithelial ovarian cancer, though patients in the early stage have an excellent prognosis, patients with advanced disease have a poor outcome and the molecular mechanism remains unclear. In this study, we retrieved database and found a secretory protein TFF1, which plays a tumor suppressor role in gastric cancer, is highly expressed in mucinous...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- American journal of cancer research
دوره 6 10 شماره
صفحات -
تاریخ انتشار 2016